The first students were enrolled in The Mandl School for Doctor's Assistants in 1924. Mr. M.M. Mandl, a biology teacher, established the school to fill the need for trained assistants to work in physician's offices. This training was not being provided by healthcare or nursing schools. Mr. Mandl believed that a school that provided healthcare or nursing certifications could train students to work in the medical world. This would prove to be a benefit for young people entering a highly competitive and modern work force. As a long time educator, he knew that education needed to lead to jobs, as well as intellectual development and personal growth.

Mr. Mandl realized that physicians required personnel trained in routine medical procedures, the operation of medical apparatus and in office management. With an assistant in the office, physicians were free to devote more time to the examination and treatment of patients. By providing thorough and comprehensive schooling, Mr. Mandl was able to free the physicians from the time and expense of training nursing personnel.